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- M. Sujatha
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- M. S. Anand
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- M. Beena Devi
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- C. Manishekar
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- B. Srinivas
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- A. Narsimha
- A. Ravi Kumar
- S. Geetha
- R. Asokan
- Anil Rai
- Sangeetha Dash
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- Sanjay Kumar Pradhan
- M. S. Parvathy
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Journals
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Ashok, K.
- Effect of Aging on Andrographolide Content in Andrographis paniculata
Abstract Views :498 |
PDF Views:739
Authors
Source
Journal of Natural Remedies, Vol 2, No 2 (2002), Pagination: 179-181Abstract
Objective: The experiment was conducted to know the effect of aging on andrographolide content in Andrographis paniculata (Kalmegh) to establish the best harvesting time. Materials and method: The growth and yield parameters were studied at 30, 60, 90, 120 and 150 days after sowing. The andrographolide content was estimated by HPLC method. Results and conclusion: The best harvesting time was observed at 120 days after sowing to get higher biomass containing maximum andrographolide content.Keywords
Andrographis paniculata, Andrographolide Content, Aging- Formulation and Characterization of Solid Lipid Nanoparticles
Abstract Views :197 |
PDF Views:83
Authors
Affiliations
1 D.C.R.M Pharmacy College, Inkollu - 523 167, Prakasam Dt., Andhra Pradesh, IN
2 QIS College of Pharmacy, Ongole - 523 001, Prakasam Dt., Andhra Pradesh, IN
1 D.C.R.M Pharmacy College, Inkollu - 523 167, Prakasam Dt., Andhra Pradesh, IN
2 QIS College of Pharmacy, Ongole - 523 001, Prakasam Dt., Andhra Pradesh, IN
Source
Journal of Pharmaceutical Research, Vol 12, No 4 (2013), Pagination: 128-133Abstract
In view of increasing bioavailability and percentage drug release by lymphatic drug delivery, Fosinopril loaded solid lipid nanoparticles were prepared by solvent emulsification and evaporation method. In vitro drug release studies revealed that 80% of the drug was being released from the optimized Fosinopril loaded solid lipid nanoparticles (SLNs) in 24hours. Optimized formulation and process parameters resulted in the production of Fosinopril loaded solid lipid nanoparticles with average particle size of 178.8 nm, zeta potential of -21mV and entrapment efficiency of 91.64% of 10 mg loading. In vitro characterization was carried out to evaluate the stability and release characteristics and kinetics. To analyze the release kinetics of drug from SLNs, drug release data was fitted into zero order, Korsmeyer-Peppas equation. Possible mechanisms for drug release might be anomalous diffusion or non-fickian diffusion. FTIR spectra, DSC thermograms revealed no significant interaction between drug and excipients. TEM photographs exhibited nanosized particles of Fosinopril. The stability studies performed for optimized SLN formulation at 4°C, 25°C, showed no significant change in % entrapment efficiency for one month. So, it was concluded that the optimized SLN formulation offers an efficient mode of delivery to the lipophilic antihypertensive drug, Fosinopril.Keywords
Fosinopril, Solid Lipid Nanoparticles, Solvent Emulsification and Evaporation, Anti Hypertensive Drug.- FPGA Implementation of Embedded Communication System
Abstract Views :164 |
PDF Views:3
Authors
Affiliations
1 Dept.of ECE, Pondicherry Engineering College, Puducherry, IN
1 Dept.of ECE, Pondicherry Engineering College, Puducherry, IN
Source
Programmable Device Circuits and Systems, Vol 2, No 2 (2010), Pagination: 38-47Abstract
A modem modulates outgoing digital signals from a computer or other digital device to analog signals and demodulates the incoming analog signal and converts it to a digital signal for the digital device. Almost all the modems implemented on field programmable gate array (FPGA) concentrate only on the modulation and demodulation part. They do not take into account the processes involved before modulation at the transmitting end and the processes involved after the demodulation at the receiving end. This paper aims at implementing and testing a programmable modulation scheme using SpartanXC3S500E FPGA. The modulation scheme adopted in this paper/work is quadrature phase shift keying (QPSK). A modem is implemented on the FPGA to test the modulation scheme and a reduced instruction set computing processor (RISC) is used to program the modem. The feature of this implementation is the realization of a complete communication system which considers all the features right from packet formation to modulation at the transmitting end to the recovery and error free reconstruction of the transmitted message at the receiving end.Keywords
FPGA, Modem, QPSK Modulation RISC Processor.- Fluoride Distribution in the Groundwater of Gangadhara Area, Karimnagar District, Telangana, India
Abstract Views :137 |
PDF Views:122
Authors
V. Sudarshan
1,
B. Srinivas
1,
S. Shankar
1,
A. Narsimha
1,
A. Ravi Kumar
1,
S. Geetha
2,
K. Ashok
1
Affiliations
1 Department of Applied Geochemistry, Osmania University, Hyderabad-500007, Telangana, IN
2 Department of Chemistry, MVSR College of Engineering, Nadergul, Hyderabad-501510, IN
1 Department of Applied Geochemistry, Osmania University, Hyderabad-500007, Telangana, IN
2 Department of Chemistry, MVSR College of Engineering, Nadergul, Hyderabad-501510, IN
Source
International Journal of Earth Sciences and Engineering, Vol 9, No 2 (2016), Pagination: 568-573Abstract
Hydrogeochemical investigations have been carried out in parts of Karimnagar district of Telangana to study the distribution of fluoride in groundwater of Gangadhara area. Eighty five groundwater samples were analyzed in January, 2013 (post-monsoon) and also in June, 2013 (pre-monsoon) for pH, Ec and Fluoride. It is observed that the groundwater in both the seasons is alkaline in nature. 39% of groundwater in post- monsoon and 23.52% of groundwater in pre-monsoon has higher concentration of Electrical conductivity than the prescribed limit. The higher values indicate that ionic concentrations are more in the groundwater. Nearly 65% of groundwater has more than the permissible limits of fluoride prescribed for drinking purpose in both post-monsoon and pre-monsoon seasons in the study area.Keywords
Pre-Monsoon, Post-Mnsoon, Groundwater, Granitic Terrain, Fluoride Distribution, Electrical Conductivity, Karimnagar District, Telangana.- Application of Genome Editing In Entomology
Abstract Views :113 |
PDF Views:68
Authors
R. Asokan
1,
Anil Rai
2,
Sangeetha Dash
1,
M. Manamohan
1,
K. Ashok
1,
C. N. Bhargava
1,
Rohan Wishard
1,
Sanjay Kumar Pradhan
1,
M. S. Parvathy
1
Affiliations
1 ICAR-Indian Institute of Horticultural Research, Hesaraghatta Lake (PO), Bengaluru 560089, Karnataka, IN
2 ICAR-Indian Agricultural Statistics Research Institute, New Delhi 110012, IN
1 ICAR-Indian Institute of Horticultural Research, Hesaraghatta Lake (PO), Bengaluru 560089, Karnataka, IN
2 ICAR-Indian Agricultural Statistics Research Institute, New Delhi 110012, IN
Source
Indian Journal of Entomology, Vol 84, No S1 (2022), Pagination: 96-103Abstract
Genome editing mediated by programmable CRISPR/Cas system is a new, emerging technology that holds greater potential in developing genetic pest management strategies via precision guided sterile insect technique; genetic improvement of pollinators, natural enemies etc. The seemingly innocuous prokaryotic immunity has now been translated into a mammoth site specific editing technology for its use in medical, agricultural, diagnostic fields etc. Until recently most of the genome editing work was dependent on RNA directed site specific cleavage by Cas9 enzyme followed by error prone, non-homologous end joining (NHEJ) resulting in random mutations. Later development of improved editing systems like base editor and prime editor have enabled obtaining site-specific, pre determined mutations without a double stranded break. Similarly many engineered Cas9 variants and other Cas proteins belonging to different class and types such as Cas3, Cas12a, Cas13a have improved the existing editing tool box. Currently efforts are being made to design and implement suitable gene drive methods for various pests such as spotted wing Drosophila, Drosophila suzukii Matsumura, Diamondback moth, Plutella xylostella (Linnaeus) , many species mosquito, Med fly, Ceratitis capitata Wiedem etc..Keywords
CRISPR/Cas systems, genome editing, double strand break, guide RNA, gene knockout, insect pest management, PAM sequence, non-homologous pairingReferences
- Baena-lopez L A, Alexandre C, Mitchell A, Pasakarnis I, Vincent J P. 2013. Accelerated homologous recombination and subsequent genome modification. Drosophila Development 140: 4818-4825.
- Bassett A R, Tibbit C, Ponting C P, Liu J L. 2013. Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Reports 4: 220-228.
- Cong I, Ran F A, Cox D, Lin S, et al. 2013, Multiplex genome engineering using CRISPR/Cas systems. Science 339(6121): 819-823.
- Dong S Z, Lin J Y, Held N L, Clem R J, et al. 2015. Heritable CRISPR/Cas9 mediated genome editing in the yellow fever mosquito, Aedes aegypti. PLoS One 10(3): e0122353. doi:10.1371/journal.pone.0122353
- Gaj T, Gersbach C A, Barbas C F. 2013. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends in Biotechnology 31(7): 397-405.
- Ishino Y, Shinagawa H, Makino K, Amemura M, Nakata A. 1987. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. Journal of Bacteriology 169 (12): 5429-5433.
- Ishino Y, Krupovic M, Forterre P. 2018. History of CRISPRCas from encounter with a mysterious repeated sequence
- to genome editing technology. Journal of Bacteriology . https://doi.org/10.1128/JB.00580-17
- Kistler K E, Vosshall L B, Matthews B J. 2015. Genome engineering with CRISPR-Cas9 in the mosquito Aedes aegypti. Cell Reports 11(1): 51-60.
- Lander E S. 2016. The Heroes of CRISPR. Cell https://doi.org/10.1016/j.cell.2015.12.041
- Ledford H. 2015. Alternative CRISPR system could improve genome editing. Nature 526(7571): 17.
- Makarova K S, Wolf Y I, Iranzo J. 2020. Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants. Nature Reviews Microbiology 18: 67-83.
- Oye K A, Esvelt K, Appleton E, Catteruccia F, et al. 2014. Regulating gene drives Science 345 (6197): 626-628.
- Biology and Morphometrics of Spodoptera litura (F.) on Castor
Abstract Views :99 |
PDF Views:74
Authors
K. Ashok
1,
S. Pavithran
1
Affiliations
1 Department of Agricultural Entomology, Tamil Nadu Agricultural University, Coimbatore 641003, Tamil Nadu, IN
1 Department of Agricultural Entomology, Tamil Nadu Agricultural University, Coimbatore 641003, Tamil Nadu, IN
Source
Indian Journal of Entomology, Vol 84, No 2 (2022), Pagination: 456-458Abstract
Biology and morphometrics of Spodoptera litura (F.) was studied by rearing it on castor under laboratory conditions. Morphology of life stages i.e., egg, larva, pupa and adult along with development period were observed. The width of head capsule was observed at each moult as 0.19, 0.25, 0.45, 0.71, 1.31 and 2.13 mm, respectively. The mean growth ratio of S. litura was observed as 1.64, which indicated that increase in head width in instars was only slightly varying from Dyar’s law.Keywords
Spodoptera litura, Castor, Biology, Morphometrics, Life Stages, Instars, Head Capsule, Growth Ratio, Dyar`s Law.References
- Abhishek S, Patel P R. 2011. Biology, food utilization and seasonal incidence of Spodoptera litura (Fab.) on banana. Research Journal of Agricultural Sciences 2(1): 49-51.
- Ashwini S B, Ashoka J, Bheemanna M, Hanchinal S G, Diwan J R. 2016. Biology and morphometry of Spodoptera litura (Fab.) on cabbage. Environment and Ecology 34(4): 1764-1767.
- Balasubramanian G, Chelliah S, Balasubramanian M. 1984. Effect of host plants on the biology of Spodoptera litura Fabricius. Indian Journal of Agricultural Science 54(12): 1075-1080.
- Chari M S, Patel N G. 1983. Cotton leaf worm Spodoptera litura (Fab.) its biology and integrated control measures. Cotton Development 13: 7-8.
- Daly H V. 1985. Insect morphometrics. Annual Review of Entomology 30: 415-438.
- Dyar H C. 1890. The number of molts of lepidopterous larvae. Psyche 5: 420-422.
- Etman A A, Hooper G H S. 1980. Developmental and reproductive biology of Spodoptera litura (F.) (Lepidoptera: Noctuidae).Australian Journal of Entomology 18(4): 363-372.
- Khorasiya S G, Vyas H J, Jetha D M, Joshi P H. 2014. Biometrical analysis of Helicoverpa armigera (Hubner) Hardwick on pigeonpea.International Journal of Plant Protection 7(2): 393-396.
- Thakur B. 2016. The study of head capsule width of different larval instars of Indian Gypsy Moth Lymantria obfuscate Walker in Himachal Pradesh (India). Journal of Entomology and Zoology Studies 4(1): 42-46.
- Tithi D A, Amin M R, Hossain S M A, Azad H M S. 2010. Consequence of Spodoptera litura Fabricius (Lepidoptera: Noctuidae) morphometrics reared on different cotton varieties. Our Nature 8(1): 118-121.
- Tuan S J, Li N J, Yeh C C. (2015). Growth performance and biometric characteristics of Spodoptera litura (Lepidoptera: Noctuidae) reared on different host plants. Journal of Economic Entomology 108(5): 2242-2249.
- Xue M, Pang Y H, Wang H T, Li Q L, Liu T X. 2010. Effects of four host plants on biology and food utilization of the cutworm, Spodoptera litura. Journal of Insect Science 10(1): 22.
- Yadav D S, Kamte A S, Jadhav R S. 2012. Bio-efficacy of cyantraniliprole a new molecule against Scelodonta strigicollis Motschulsky and Spodoptera litura Fabricius in grapes. Pest Management in Horticultural Ecosystems 18: 128-134.